10 mg "loading dose" when starting warfarin in outpatients with venous thromboembolism

A controversial new study recommends a 10 mg "loading dose" when starting warfarin in outpatients with venous thromboembolism.

Patients with venous thromboembolism are usually started on 5 mg of warfarin...then titrated to a therapeutic INR.

Starting with a higher 10 mg dose for two days seems to achieve a therapeutic INR faster.

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