Clarify Antiemetics for PONV Prevention

November 2023

The new IV aprepitant (Aponvie) will raise questions about how to PREVENT postoperative nausea and vomiting (PONV) in adults.

This NK-1 receptor antagonist is an IV push alternative to oral aprepitant (Emend) for PONV prevention.

Both have a longer half-life than many other PONV meds.  But IV aprepitant may be more convenient, since it’s given just before anesthesia...versus up to several hours prior with oral aprepitant.

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